Greenstein Lab
Principal Investigator: David Irwin Greenstein
Institution: University of Minnesota (Minneapolis, MN)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
SUMMARY/ABSTRACT Overview: Reproduction relies on a complex series of cell fate decisions, cell cycle transitions, and differentiation events, which coordinate the formation and function of gametes with the process of meiosis. A century of research using many experimental organisms, including the nematode Caenorhabditis elegans, defined key intercellular signals regulating germline development, delineated central players in meiosis, and revealed the importance of post-transcriptional gene regulatory mechanisms. Yet, important mechanistic questions remain about how intercellular communication integrates the underlying molecular mechanisms into a coherent germline developmental program. This research proposal addresses several central questions: •How do soma-germline gap junctions orchestrate germline development, coordinate germline developmental subroutines, and integrate nutritional signals to optimize reproduction? •How do intercellular signals and gametic interactions regulate protein translation to enable fertilization and ensure the vitality of the embryo? •Can we exploit the dynamic nature of germline development in which germ cell nuclei move within the gonadal tube to provi…
Active NIH Awards
- 5R35GM144029-05: The C. elegans Germline: A Test Tube for Cell and Developmental Biology (2026)
- 5R35GM144029-04: The C. elegans Germline: A Test Tube for Cell and Developmental Biology (2025)
- 5R35GM144029-03: The C. elegans Germline: A Test Tube for Cell and Developmental Biology (2024)
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