Jameson Lab
Principal Investigator: Stephen C Jameson
Institution: University of Minnesota (Minneapolis, MN)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
SUMMARY The Administrative Core (Core A) will serve as the hub of the proposed NIAID PPG entitled “The Role of Senescent Cells in Dysregulating Immune Response and Pathogen Control” comprised of three research projects and two research resource Cores (Cores B and C). The PIs of Core A are Dr. Stephen Jameson, Professor in the Department of Laboratory Medicine and Pathology at UMN and an expert in adaptive immune responses to pathogens, and Dr. Laura Niedernhofer, Director of the Institute on the Biology of Aging and Metabolism (iBAM) at UMN, an expert in cellular senescence and mouse models of accelerated senescence and aging. Both have led and/or been involved in several NIH P and U series grants. Overall, this PPG will examine the effect of age and increased senescent cell (SnC) burden on immune function. To do so, we propose an interdisciplinary approach combining the expertise of leaders in the fields of the biology of aging and immunology, leveraging the synergies provided by these interactions coordinated around two Scientific Cores (one for sophisticated transgenic models and pathogen exposure paradigms, the other for complex single-cell and spatial analysis of tissues). The…
Active NIH Awards
- 5P01AI172501-03: Admin Core (2026)
- 5R01AI038903-30: T Cell Homeostasis (2026)
- 5P01AI172501-03: Effect of senescent cells (2026)
- 1R21AI196205-01: Differentiation and characteristics of Helios+ CD8+ T cells (2026)
- 5R01AI187400-02: Non-deletional CD8+ T cell tolerance (2026)
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