Parker Lab
Principal Investigator: Laurie L. Parker
Institution: University of Minnesota (Minneapolis, MN)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary/Abstract My laboratory works at the interface of chemistry and biology on technology development for post-translational modification enzyme activity measurement. We use a broad variety of techniques including peptide chemical biology, spectroscopy, proteomics, cell biology, and analytical chemistry to create tools that help answer biological questions with molecular precision. We have spent the most time on studying and building a toolkit for measuring kinase activity, both in vitro and in live cells. We are currently working on building out our platform technology called KINATEST-ID to characterize kinase preferences, design novel substrates, and apply them in kinase assays with innovative read-outs. Our goals for the next five years are (1) to build up our understanding of kinase-substrate interactions using multiple avenues: in vitro phosphoproteomics experiments to characterize the substrate profiles of many different kinases, comparing substrate preference motifs to try to dissect differences, designing novel artificial substrate tools that could distinguish between the activities of different kinases, and using cutting-edge artificial intelligence-based struct…
Active NIH Awards
- 5R35GM158262-02: Tools for measuring post-translational modification enzyme activity in vitro and in cells (2026)
- 1R35GM158262-01: Tools for measuring post-translational modification enzyme activity in vitro and in cells (2025)
- 5R01GM146386-04: Multiplexed proteomics-based kinase assay development (2025)
- 3R01GM146386-04S1: Multiplexed proteomics-based kinase assay development (2025)
- 5R01GM146386-03: Multiplexed proteomics-based kinase assay development (2024)
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