Bulik Lab
Principal Investigator: Cynthia M Bulik
Institution: University of North Carolina at Chapel Hill (Chapel Hill, NC)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
We propose the Eating Disorders Genetics Initiative 2 (EDGI2), a new collaborative R01 in response to PAR-23-050. Its predecessor, EDGI1 (R01 MH120170) was highly successful. We now include global sites to advance discovery across all major eating disorders (EDs) to identify biologically, clinically, and therapeutically actionable insights. Including foreign sites is essential scientifically: sample sizes required to detect genetic variants of small effect, that can have major health implications for Americans, can only be achieved through global collaboration. Findings will accelerate genetic insights that benefit US patients with EDs. Aim 1: Using our comprehensive online platform, EDGI2 will enroll and bio-sample 20,000 new participants with anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), avoidant/restrictive food intake disorder (ARFID), and controls, over-sampling people with severe and enduring AN (SE-AN), whose DNA may be enriched for causative alleles. Aim 2: Statistical genetic analyses will explicate ED heterogeneity and biology. We will conduct standard GWAS analyses on diagnoses, cross-diagnostic behaviors, and continuous traits including polyg…
Active NIH Awards
- 5R01MH136149-03: 1/3 Eating Disorders Genetics Initiative 2 (EDGI2) (2026)
- 5R01MH136149-02: 1/3 Eating Disorders Genetics Initiative 2 (EDGI2) (2025)
- 1R01MH136149-01: 1/3 Eating Disorders Genetics Initiative 2 (EDGI2) (2024)
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