Nimchuk Lab
Principal Investigator: Zachary Luke Nimchuk
Institution: University of North Carolina at Chapel Hill (Chapel Hill, NC)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary How cell to cell signaling networks control stem cell maintenance and development is a fundamental question in biology. Cell to cell communication and stem cell maintenance are critical for human development and both contribute to disease states when disrupted. The ability to manipulate cell signaling pathways or utilize stem cells to treat human disease remain outstanding goals. As such, understanding how cell to cell signaling networks function is critical for diverse public health challenges. My lab uses the well-established and tractable model plant system, Arabidopsis, to take a multi-level approach to dissect the receptor kinase pathways that control development and stem cell proliferation. Arabidopsis offers many technical benefits which make the dissection of such signaling networks feasible. In addition, stem cell niches and other developing tissues can be monitored live in whole organisms and are easily accessible and amenable to experimental manipulation in a manner not feasible for many models. The proposal will support a series of projects that collectively aim to understand the function of peptide receptor kinase signaling in stem cell regulation and d…
Active NIH Awards
- 5R35GM119614-10: Receptor kinase signal integration in stem cell maintenance and development. (2026)
- 5R35GM119614-09: Receptor kinase signal integration in stem cell maintenance and development. (2025)
- 5R35GM119614-08: Receptor kinase signal integration in stem cell maintenance and development. (2024)
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