Zhu Lab
Principal Investigator: Hongtu Zhu
Institution: University of North Carolina at Chapel Hill (Chapel Hill, NC)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Summary/Abstract Despite significant advances in omics studies and laboratory observations, identifying the causal mechanisms for late-on- set Alzheimer's disease (AD) and AD-related dementia (ADRD) remains a challenge due to their multifactorial inheri- tance, which is heterogeneous across subjects and populations. In dementia studies, only a subset of relevant data is typi- cally collected from each participant, resulting in a biased exploration of AD pathogenesis. To address these limitations and respond to the NOT-AG-21-045 call for proposals on harmonizing complex data sets relevant to AD/ADRD, we pro- pose the development of a comprehensive AD-related knowledge graph (AD-KG) platform. This platform will inte- grate and harmonize data from multiple curated resources, literature, and a large-scale AD-related database with multiple types of high-dimensional data, including imaging, genetics, and clinical variables, from different studies with different missing-data patterns. Our inspiration for this proposal comes from the success of knowledge graphs (KGs) as a foundation for cognitive systems in industry, such as Microsoft XiaoIce. We propose to achieve four aims: Aim 1…
Active NIH Awards
- 5R01AG085581-03: Construction and Application of Comprehensive Knowledge Graphs for Alzheimer's Disease (2026)
- 4RF1AG082938-02: Mapping the Causal Genetic-Imaging-Clinical Pathway for Alzheimer's Disease (2026)
- 5R01AG085581-02: Construction and Application of Comprehensive Knowledge Graphs for Alzheimer's Disease (2025)
- 1R01AG085581-01: Construction and Application of Comprehensive Knowledge Graphs for Alzheimer's Disease (2024)
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