Ebrahimkhani Lab
Principal Investigator: Mo Reza Ebrahimkhani
Institution: University of Pittsburgh (Pittsburgh, PA)
Primary Subfield: Synthetic Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project summary/ abstract: Organoids reproduce the complex differentiation, cell sorting and self-organization of organogenesis, enabling the study of tissue development and modeling of organ physiology and disease ex vivo. The induced human Pluripotent stem cell (ihPSC) derived organoids are on their way to revolutionizing the future of human cell/organ transplantations. However, a major challenge is centered around the limited ability to control and direct the dynamic process of self-organization at the cellular population level. This drawback diminishes our engineering efforts to build reliable human tissues by mimicking natural biological processes. As such, currently, human organoids exhibit (a) aberrant cell types and (b) stalled developmental stages (immaturity) (c) limited robustness and reproducibility during multilineage tissue formation. In this proposal, we will harness the power of synthetic and system biology and provide a framework to build next-generation organoids with augmented performance and robustness for regenerative medicine. Our method is guided by computational models and genetic technologies. We have recently discovered that in our liver organoids, GATA6-e…
Active NIH Awards
- 5R01DK139590-07: Integration of Systems and Synthetic Biology to Advance Development of Human Tissues In Vitro (2026)
- 2R01HL141805-06: Recreating Human Developmental Hematopoietic Niches for Ex Vivo Biomanufacturing of Blood Stem Cells (2026)
- 5R01DK139590-06: Integration of Systems and Synthetic Biology to Advance Development of Human Tissues In Vitro (2025)
- 9R01DK139590-05: Integration of Systems and Synthetic Biology to Advance Development of Human Tissues In Vitro (2024)
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