Vogt Lab
Principal Investigator: Keith Michael Vogt
Institution: University of Pittsburgh (Pittsburgh, PA)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary This ESI MIRA program of research, within the field of anesthesiology and perioperative pain, is aimed at better understanding how anesthetic and analgesic agents block memory formation, prevent conditioned fear responses, and relieve pain during otherwise unbearable experiences. Current provision of clinical anesthesia is not universally effective in achieving these goals because of a critical knowledge gap in understanding the systems-level neuroscience of how these drugs act and interact. The PI is a physician-anesthesiologist and bioengineer who has established a unique and innovative interdisciplinary framework to address this important problem. A team of senior collaborators, with expertise in psychology, functional MRI analysis, MRI engineering, and anesthetic pharmacology has been assembled to take advantage of an extremely productive academic environment. The project will determine how anesthetics from the seven major mechanistic classes of clinically- used agents act and interact to affect cognitive functions, including where in the brain changes occur. Steady- state concentrations of anesthetics will be delivered in a high-field MRI environment, while sub…
Active NIH Awards
- 5R35GM146822-05: Neuroimaging to identify the neural correlates of anesthetic and analgesic action in humans (2026)
- 5R01AT013058-02: A mechanistic neuroimaging study to determine brain changes with auricular stimulation and auriculotherapy in healthy volunteers and chronic low back pain patients (2026)
- 5R35GM146822-04: Neuroimaging to identify the neural correlates of anesthetic and analgesic action in humans (2025)
- 1R01AT013058-01: A mechanistic neuroimaging study to determine brain changes with auricular stimulation and auriculotherapy in healthy volunteers and chronic low back pain patients (2025)
- 5R35GM146822-03: Neuroimaging to identify the neural correlates of anesthetic and analgesic action in humans (2024)
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