Xing Lab
Principal Investigator: Jianhua Xing
Institution: University of Pittsburgh (Pittsburgh, PA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
Understanding how cells respond to environmental changes is a fundamental task in systems biology and has profound biomedical implications. Mathematical modeling on small network motifs using dynamical systems theories has been successful on providing mechanistic insight and guidance, but generalization to a genome- wide intertwined gene regulatory network is challenging. Single cell genomics approaches emerge as powerful tools for studying cellular processes, but the destructive nature of most single cell techniques makes it unfeasible to extract dynamical information of cellular processes. In addition, a number of grand challenges impede further development of the field, such as trajectory inference, effect of various sources of errors on data analysis, and validating and benchmarking tools for single cell measurements and analyses. The goal of this proposed research is to tackle these challenges through integrating dynamical systems modeling into single cell genomics analyses. The proposed research is based on recent advances in the single cell genomics field that one can extract both transcriptome (x) and estimation of RNA velocity (i.e., instant time derivatives of transcripto…
Active NIH Awards
- 5R01GM148525-04: Learn Systems Biology Equations From Snapshot Single Cell Genomic Data (2026)
- 5R01GM148525-03: Learn Systems Biology Equations From Snapshot Single Cell Genomic Data (2025)
- 5R01GM148525-02: Learn Systems Biology Equations From Snapshot Single Cell Genomic Data (2024)
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