Detre Lab
Principal Investigator: John A Detre
Institution: University of Pennsylvania (Philadelphia, PA)
Primary Subfield: Synthetic Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
SUMMARY Arterial spin labeled (ASL) perfusion MRI provides noninvasive quantification of tissue blood flow in physiological units of ml/100g/min using magnetic labeling of blood water as an endogenous diffusible flow tracer, and is one of the few MRI parameters whose biological basis is known. ASL MRI has primarily been used in the brain to measure cerebral blood flow (CBF), a key physiological parameter that serves a biomarker of cerebrovascular integrity and regional brain function with a broad range of applications in basic and clinical neuroscience research and in clinical care. ASL MRI was originally conceived by our laboratory at the University of Pennsylvania, and we have been responsible for demonstrating many of its technical advances and applications in biomedical research. Although ASL MRI has been translated to clinical use, commercial ASL MRI technologies have failed to keep up with research progress. In response to the special funding mechanism: PAR-18-530, this Academic Industrial Partnership project will provide dedicated resources to further develop, maintain, and deliver state-of-the-art ASL MRI acquisition and processing technologies for clinical research on the…
Active NIH Awards
- 5R01EB031080-05: Academic Industrial Partnership on Advanced Perfusion MRI (2026)
- 5R01EB031080-04: Academic Industrial Partnership on Advanced Perfusion MRI (2025)
- 5P30AG072979-05: Neuroimaging Core (2025)
- 3R01EB031080-03S1: Academic Industrial Partnership on Advanced Perfusion MRI (2024)
- 5R01EB031080-03: Academic Industrial Partnership on Advanced Perfusion MRI (2024)
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