Stern Lab
Principal Investigator: Lawrence A Stern
Institution: University of South Florida (Tampa, FL)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Summary Advances in computational and experimental protein engineering have ushered in a new era of biomolecule development, providing new functional binding proteins, improved enzymes, and rationally designed synthetic receptors. Despite such progress, established techniques lack the ability to develop and study synthetic receptors and inhibitory molecules in high throughput, instead relying on rational or function-agnostic engineering approaches followed by low-throughput characterization for the desired activity. This deficiency in approach results in 1) the development of suboptimal candidate proteins and 2) a costly development process. My long-term goals are to 1) establish new platforms that incorporate protein function as a selective pressure to engineer new molecules and 2) utilize these new platforms to understand the roles of natural and synthetic proteins in cell signaling responses in both normal and disease pathologies. I hypothesize that the incorporation of protein function as a selective pressure in protein engineering campaigns will result in the efficient development of new classes of functional proteins capable of answering key biological questions. The…
Active NIH Awards
- 5R35GM147104-05: High-Throughput Platforms to Study Synthetic Receptors, Natural Molecules, and New Pathway Inhibitors (2026)
- 5R35GM147104-04: High-Throughput Platforms to Study Synthetic Receptors, Natural Molecules, and New Pathway Inhibitors (2025)
- 5R35GM147104-03: High-Throughput Platforms to Study Synthetic Receptors, Natural Molecules, and New Pathway Inhibitors (2024)
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