Golkowski Lab
Principal Investigator: Martin Golkowski
Institution: University of Utah (Salt Lake City, UT)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROGRAM ABSTRACT: Integrated mass spectrometry-based chemoproteomic and genomic technologies for studying dynamic kinase interactomes Dynamic changes in protein-protein and protein-DNA interactions (PPIs and PDIs) control most cellular processes, including cell signaling and transcription; devastating diseases rewire PPI and PDI networks to drive disease progression, therapy resistance, and immune escape. Novel methods for mapping dynamic interaction networks are, therefore, urgently required to identify disease mechanisms and drug targets. Protein kinases are critical regulatory nodes in most cellular PPI and PDI networks, are often dysregulated in disease, and are highly druggable with synthetic, ATP-competitive inhibitors. Insights into how diseases utilize kinases to rewire PPI and PDI networks are extremely relevant for combating many diseases. Advances in quantitative mass spectrometry (MS) have revolutionized proteomics, yet facile methods for the systematic, sensitive, and high-throughput profiling of kinase PPIs, locus-specific PDIs, and their dynamics are lacking. We will develop transformative methods that combine cell-permeable affinity probes with chemical crosslinking…
Active NIH Awards
- 5R35GM150766-04: Integrated mass spectrometry-based chemoproteomic and genomic technologies for studying dynamic kinase interactomes (2026)
- 5R35GM150766-03: Integrated mass spectrometry-based chemoproteomic and genomic technologies for studying dynamic kinase interactomes (2025)
- 5R35GM150766-02: Integrated mass spectrometry-based chemoproteomic and genomic technologies for studying dynamic kinase interactomes (2024)
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