Tambar Lab
Principal Investigator: Uttam Krishan Tambar
Institution: The University of Texas Southwestern Medical Center (Dallas, TX)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
The development of innovative chemical reactions is critical to advancing drug discovery and improving human health. Our laboratory focuses on addressing unmet needs in basic biomedical research through the development of selective chemical methods that impact drug discovery in two transformative ways. Research Direction 1: Stereoselective synthesis of sp3-rich N-heterocycles via photocatalytic C–H annulation We propose to develop stereoselective catalytic reactions to synthesize chiral N-heterocycles, a class of sp³- rich scaffolds prevalent in FDA-approved drugs. Our strategy employs enantioselective photocatalytic C–H annulations mediated by dual photoredox and chiral Lewis acid catalysis to generate functionalized N- heterocycles with diverse substitution patterns and stereochemical complexity. This research direction will provide streamlined access to several classes of saturated heterocycles, including morpholines, piperidines, pyrrolidines, tetrahydroquinolines, and indolines. Insights gained from mechanistic studies will inform the development of highly stereoselective processes. Research Direction 2: Late-Stage Photochemical Installation of Photocrosslinkers into Drug-Like…
Active NIH Awards
- 1R35GM161642-01: Chemical Reactions to Advance Drug Discovery: Stereoselective Synthesis of Heterocycles and Late-Stage Functionalization for Mechanism of Action Studies (2026)
- 5R01GM102604-13: Stereoselective Photochemistry for the Synthesis of Bioactive Molecules (2024)
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