Georgiev Lab
Principal Investigator: Ivelin Georgiev
Institution: Vanderbilt University Medical Center (Nashville, TN)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary. The human immune system participates in complex interactions with virtually all other systems in the body. In particular, the B cell component of the adaptive immune response plays a role in various disease settings, including infectious disease, cancer, autoimmunity, cardiovascular, hematologic, neurologic diseases, and others. In addition, antibodies (a product of B cells) are effectively used in diagnostics, therapy, and prevention. Yet, despite decades of antibody discovery efforts, there is still very limited data linking human antibody sequence to antigen specificity (the preferential recognition of target antigens by a given antibody). One of the major reasons for such limited data is the fact that even high- throughput antibody sequence identification methods such as next-generation sequencing (NGS) of B cell receptor (BCR) sequences are generally decoupled from the process of antibody functional characterization. As a result, even though there are typically thousands to millions of antibody sequences within a single NGS dataset, functional information is obtained only for a handful of antibodies against not more than 2-3 target antigens at a time. To addre…
Active NIH Awards
- 5R01AI175245-04: Technologies for High-Throughput Mapping of Antigen Specificity to B-Cell-Receptor Sequence (2026)
- 1R01AI189373-01A1: Development of cross-protective antibodies for respiratory viruses of biomedical significance (2026)
- 5U19AI174999-04: Core 3: Single-Cell Core (2026)
- 5R01AI175245-03: Technologies for High-Throughput Mapping of Antigen Specificity to B-Cell-Receptor Sequence (2025)
- 5U19AI174999-03: Core 3: Single-Cell Core (2025)
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