Glazer Lab
Principal Investigator: Andrew M. Glazer
Institution: Vanderbilt University Medical Center (Nashville, TN)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY Ion channels pass charged ions through lipid membranes in a regulated manner. Ion channels play major roles in regulating electrically excitable tissues, sensing and responding to the environment, and maintaining cell homeostasis. Over 70 ion channels have been linked to Mendelian “channelopathy” disorders, affecting a diverse set of organ systems. As genetic testing and genomic medicine become prominent, an important challenge is to understand the spectrum of which mutations in ion channel genes cause disease. Unfortunately, a large fraction of variants are currently annotated as “Variants of Uncertain Significance,” which limits the effectiveness and potential of genomic medicine. This proposal seeks to decipher which variants in channelopathy genes cause disease. We will first use large biobank datasets with linked genome sequencing and phenotype data. We will examine associations between genetic variants in 76 channelopathy genes and relevant disease phenotypes. Using control pathogenic variants, we will first determine which gene-phenotype pairs are associated in biobank datasets, then discover novel candidate disease-associated variants that are present in car…
Active NIH Awards
- 5R35GM150465-04: High-throughput discovery of disease-associated ion channel variants (2026)
- 5R35GM150465-03: High-throughput discovery of disease-associated ion channel variants (2025)
- 5R00HG010904-05: A pipeline for identifying disease-causing variants in transmembrane proteins (2024)
- 5R35GM150465-02: High-throughput discovery of disease-associated ion channel variants (2024)
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