Horne Lab
Principal Investigator: David J. Horne
Institution: University of Washington (Seattle, WA)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
SUMMARY Tuberculosis (TB) is the leading cause of death due to an infectious agent. Progress in controlling the TB epidemic has fallen short of milestones and new strategies for TB control are urgently needed. Asymptomatic TB, defined as microbiological evidence of TB in people without symptoms, has recently been recognized as common (>50% of prevalent TB) and probably a significant source of M. tuberculosis (Mtb) transmission and driver of the epidemic. There are important knowledge gaps that impede interventions to target asymptomatic TB including: 1) Determining the spectrum of asymptomatic TB infectiousness and risk factors for increased infectiousness and Mtb transmission, 2) Discovering host determinants and mechanisms associated with different outcomes in the natural history of asymptomatic TB (e.g., progression to more infectious TB versus self- resolution of disease), and 3) Developing cost-effective tools to screen for people with asymptomatic TB, especially those who are most infectious or more likely to progress to infectious states. To address these knowledge gaps, this proposal will investigate infectiousness and transmission related to asymptomatic TB, disease trajec…
Active NIH Awards
- 3R01AI200122-01S1: Asymptomatic TB Transmission, Infectiousness, and Immunology (2026)
- 1R01AI200122-01: Asymptomatic TB Transmission, Infectiousness, and Immunology (2026)
- 5P30AI168034-05: Clinical and Translational Science Core (2026)
- 5P30AI168034-04: Clinical and Translational Science Core (2025)
- 5R01AI150815-05: Aerobiology, immunology, and Mycobacterium tuberculosis transmission (2024)
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