Mccartney Lab
Principal Investigator: Stephen Andrew Mccartney
Institution: University of Washington (Seattle, WA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Summary/Abstract Metabolic programming and nutrient utilization are increasingly recognized as key determinants of immune cell function. Advances in understanding of immunometabolism have led to important therapeutic applications in oncology and rheumatology. In these diseases, changes in metabolic programming are associated with immune activation or suppression. Despite the critical role of the immune system and the significant maternal metabolic changes that occur during pregnancy, there is limited understanding of immunometabolism at the maternal-fetal interface. Immune cell function is highly dynamic during pregnancy, with pro- and anti- inflammatory phenotypes occurring at different gestational weeks. Our preliminary data demonstrate significant differences in placenta metabolite composition in each trimester. We hypothesize that metabolic changes at the maternal-fetal interface contribute to immune phenotype in pregnancy. The overall goal of this proposal is to examine how nutrient availability and utilization impacts immune cell function at the maternal-fetal interface. Our experiments will assess the combined metabolic and inflammatory phenotypes of immune cells at…
Active NIH Awards
- 1R01HD120335-01: Metabolic Regulation of Immune Cell Function at the Maternal Fetal Interface (2026)
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