An Lab
Principal Investigator: Ran An
Institution: University of Wisconsin–Madison (Madison, WI)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT ABSTRACT Voice disorders are among the most common communication disorders and estimated to affect 3-9% of Americans annually. These disorders are often associated with laryngeal inflammation secondary to epithelial injuries following phonotrauma, surgical resection, radiation, and various infectious processes. Serious injury can lead to disordered mucosal remodeling, scar formation, and a profound dysphonia. Bacterial dysbiosis, a disturbance in the microbial community structure, is implicated in a variety of inflammatory disease etiologies in mucosal systems, however, understanding of laryngeal microbiota and their protective mechanisms against mucosal inflammation remains limited. To date, laryngeal microbiome studies have been limited to characterization of microbial communities in disease states of the larynx. Research in regard to bacterial contributions to the maintenance and regeneration of laryngeal mucosa is still lacking. The overall goal of this work is to identify bacterial species associated with each stage of epithelial wound healing in the larynx and define the role of laryngeal microbiota in modulation of epithelial regeneration through a longitudinal study…
Active NIH Awards
- 5R21DC021012-03: Microbial modulation of mucosal wound healing in the larynx (2026)
- 1K99HL183753-01: Elucidating the Role of Mechanotransduction in SMC Dedifferentiation in Peripheral Artery Disease (2026)
- 5R00HL165099-04: Using miRNA to identify new therapeutic pathways for dilated cardiomyopathy (2026)
- 5R01AR083445-03: Cellular and molecular coordinators of large-scale bone repair (2026)
- 1R01CA287116-01A1: Mechanisms of immunosuppression triggered by checkpoint blockade immunotherapy (2026)
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