Chen Lab
Principal Investigator: Guanhua Chen
Institution: University of Wisconsin–Madison (Madison, WI)
Primary Subfield: Immunology
Recruitment Status: ✅ Accepting PhD Students
Research Focus
Project Summary Childhood asthma poses a significant public health burden due to its high prevalence, associated healthcare costs, and long-term impacts on children's health and development. The human microbiome has been associated with asthma phenotypes, endotypes, and disease severity, positioning it as a potential therapeutic target for asthma prevention and control, particularly since the microbiome is inherently modifiable. We recently assembled the largest and most geographically diverse datasets containing infant nasal and gut microbiomes, along with host genetics data, from multiple birth cohorts within the NIH-funded Children’s Allergy and Asthma Data Repository (CADRE). This study presents a unique opportunity for a more thorough investigation into the impact of the microbiome and its interactions with host genetics on asthma risk. Unfortunately, the statistical and computational tools for analyzing the CADRE study are currently lacking, primarily due to the complex compositional structure of microbiome data. This proposal seeks to address critical gaps in the methodological literature by focusing on three major areas. Specifically, we aim to develop a comprehensive suite…
Active NIH Awards
- 5R01AI192972-02: Novel Integrative Analysis of Microbiome and Host Genetics in Childhood Asthma Research (2026)
- 1R01GM169395-01: Distributional Balancing for Complex Causal Inference in Critical Care (2026)
- 5R01EB034011-04: Next Generation Cone Beam CT with Improved Contrast Resolution and Added Spectral Imaging Functionality (2026)
- 5R01EB034011-03: Next Generation Cone Beam CT with Improved Contrast Resolution and Added Spectral Imaging Functionality (2025)
- 5R01EB032374-04: Clinical Translation of a One-Stop-Shop Imaging Method for Abdominal CT (2025)
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