Lambert Lab
Principal Investigator: Paul F. Lambert
Institution: University of Wisconsin–Madison (Madison, WI)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
OVERALL – PROJECT SUMMARY/ABSTRACT Molecular Biology and Genetics of Human Tumor Viruses Paul F. Lambert, PI Viruses cause approximately 15% of human cancers. A viral etiology to a human cancer can have substantive consequences on its treatment and prevention. For example, many virally-caused human cancers express virally encoded products, which are potential targets for anti-viral, tumor-specific therapies. In addition, unique sets of cellular genes and pathways contribute to virally-associated cancers, many of which are currently being pursued as targets for anti-cancer therapies. This program project grant (PPG), now in its 45th year of continual funding, has two major objectives: to use molecular biology and genetics to elucidate the life cycles of and transformation by human tumor viruses and to translate this understanding into the identification of targets for specific anti-viral, anti-tumor therapies. The PPG has seven lead investigators who share these research goals in studying multiple human tumor viruses in two different virus families: papillomaviruses, and herpesviruses. Together, these viruses cause the vast majority of virally-associated human cancers. The PPG has b…
Active NIH Awards
- 5P01CA022443-48: Molecular Biology and Genetics of Human Tumor Viruses (2026)
- 5R35CA210807-10: Defining Drivers of HPV-associated Carcinogenesis (2026)
- 5P01CA022443-48: Core A - Administrative/Statistics Core (2026)
- 5P01CA022443-48: Project 1 - Characterize the Mechanism by Which Papillomaviruses Evade Host Immunity (2026)
- 5R35CA210807-09: Defining Drivers of HPV-associated Carcinogenesis (2025)
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