Cruchaga Lab
Principal Investigator: Carlos Cruchaga
Institution: Washington University in St. Louis (Saint Louis, MO)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Abstract: Genetics Core Understanding the genetic basis of CM is a major goal of these projects. Since obtaining DNA from patients and generating large amounts of sequence data will require extensive computational, bioinformatic and statistical analyses, we have established a Genetics Core to serve these critical needs. In addition, this Core will provide a major data-storage and data-sharing function for both this PPG and for investigators worldwide. This Core will have three Specific Aims. Aim 1 will focus on performing all the NGS and analysis for this PPG. The Core personnel will work closely with Project investigators in the design of proposed experiments, and will provide standard analysis for each project. Critical to this application, the Genetics Core personnel will also provide data interpretation and additional follow-up data-driven iterative analyses as are often required. This will permit major increase in efficiency by having computational biologists dedicated to this PPG; will offer an iterative approach since analysis of NGS data is complex and experiment driven and will provide consistency regarding analytic approaches. We will guarantee data storag…
Active NIH Awards
- 5P01NS131131-04: Genetics Core (2026)
- 5R01AG078964-05: Identification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy Aging (2026)
- 5R01AG058501-04: Genetic Modifiers of TREM2 in Alzheimer's Disease (2026)
- 3U01AG084514-01A1S1: CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study" (2026)
- 2P01AG003991-41: Project 3: Detailed Multi-Tissue Molecular Characterization of Clinical and Biomarker Onset and Rate of Progression (2026)
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