Colon-Ramos Lab
Principal Investigator: Daniel A Colon-Ramos
Institution: Yale University (New Haven, CT)
Primary Subfield: Neuroscience
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY A gap in knowledge remains regarding how structural organization of synapses, robustly established during development, is also flexibly modified during learning to sustain behaviors. Knowledge on how the cell biology of synapses is established and altered in the actuation of memories is of critical importance in our aspiration to understand how the building blocks of the nervous system come together to produce its functional output, behaviors. The key scientific premise of my research program is that our understanding of how complex behaviors emanate from the molecular building blocks of synapses could be meaningfully expanded by simultaneously interrogating structure-function relationships across scales, bridging knowledge on the molecular composition of individual synapses within single cells, the organization of single cells within circuits, and the coordinated activity of circuits within the brain of behaving animals. Achieving this integrated view is a challenge of critical importance best summarized in the BRAIN Working Group Report to the NIH Director, and requires new approaches that allow the integration of knowledge across 1) spatial scales, from the subce…
Active NIH Awards
- 5R35NS132156-04: Examination of the cell biology of the synapse and behavior (2026)
- 5R35NS132156-03: Examination of the cell biology of the synapse and behavior (2025)
- 5R35NS132156-02: Examination of the cell biology of the synapse and behavior (2024)
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