Lin Lab
Principal Investigator: Chenxiang Lin
Institution: Yale University (New Haven, CT)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY Lipid-bilayer membranes form diverse and dynamic structures in cells to serve vital functions including nutrient uptake, waste managements, signal transduction, and so on. Understanding the molecular mechanisms by which the cell generates and changes its membrane structures has been a central task of cell biology. It is well established that the physical and chemical properties of membranes regulate their interactions with proteins, which in turn shape the membrane landscape. However, there are still major knowledge gaps regarding how proteins act upon different membrane curvature and tension, especially when the membrane structure and/or the membrane-protein interaction are transient. Cell-free systems using reconstituted membranes provide a powerful method to study such intricate molecular interplays. However, there is still a pressing need for a precisely engineered platform that (1) exquisitely controls the geometrical, biochemical and mechanical properties of membranes and (2) easily allows for biochemical and structural characterization of membrane- associating proteins. Using DNA nanotechnology, a bottom-up method that generates three-dimensional molecular as…
Active NIH Awards
- 3R35GM149264-04S1: DNA nanotechnology enabled high-precision membrane engineering (2026)
- 5R35GM149264-04: DNA nanotechnology enabled high-precision membrane engineering (2026)
- 5R35GM149264-03: DNA nanotechnology enabled high-precision membrane engineering (2025)
- 5R35GM149264-02: DNA nanotechnology enabled high-precision membrane engineering (2024)
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