Zhang Lab
Principal Investigator: Sai Zhang
Institution: Yale University (New Haven, CT)
Primary Subfield: Computational Biology
Recruitment Status: ✅ Hiring Postdocs
Research Focus
ABSTRACT The dissection of genetic, molecular, and cellular heterogeneity in human complex diseases is imperative for understanding disease pathogenesis and advancing the therapeutics. Recent progresses in genetics and single-cell genomics have generated massive datasets, such as those from the UK Biobank and the Human Cell Atlas, providing great opportunities to investigate the genetic underpinnings of complex diseases and the cellular diversity across human tissues. However, existing computational and statistical methods are compartmentalized for genetic or single-cell data analysis, lacking a seamless integration needed to link genetic variants to specific cellular processes. This limitation impedes the differentiation of disease-causing genetic factors from confounding elements, resulting in an incomplete grasp of cellular and molecular disease mechanisms. In response, we propose a pioneering research field, “single-cell genetics,” aimed at systematically integrating cutting-edge single-cell genomic data into genetic analysis. Our goal is to develop a suite of deep learning methods, serving as the methodological foundation for single-cell genetics, to address fundamental challe…
Active NIH Awards
- 5R35GM157219-03: Deep Learning for Single-Cell Genetics (2026)
- 7R35GM157219-02: Deep Learning for Single-Cell Genetics (2025)
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